Brenda Cárdenas was born and raised in Milwaukee and has also lived in Beaver Dam, Appleton, Menasha, and Fond du Lac. She obtained her undergraduate degree at the University of Wisconsin–Milwaukee, and a Masters of Fine Arts (MFA) degree in Creative Writing (Poetry) at the University of Michigan. From 2007 to 2024 she taught Creative Writing and U. S. Latin o/x Literatures at the University of Wisconsin–Milwaukee.

A former City of Milwaukee poet laureate, Cárdenas has authored two full-length books: Trace (Red Hen Press) and Boomerang (Bilingual Press). She has also authored or co-authored three chapbooks: Bread of the Earth/The Last Colors, Achiote Seeds/Semillas de Achiote, and From the Tongues of Brick and Stone.